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Sphinganine-d7(d18:0)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Sphinganine-d7(d18:0)图片
规格:98%
分子量:308.6
包装与价格:
包装价格(元)
500ug电议
1mg电议

产品介绍
An internal standard for the quantification of sphinganine (d18:0)
货号:ajcx23490
CAS:1246304-35-7
分子式:C18H32D7NO2
分子量:308.6
溶解度:DMF: 10 mg/mL,DMSO: 2 mg/mL,Ethanol: miscible
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Sphinganine-d7(d18:0) is intended for use as an internal standard for the quantification of sphinganine (d18:0) by GC- or LC-MS. Sphinganine (d18:0) is a precursor to ceramide and sphingosine as well as a substrate of sphingosine kinases, which generate sphinganine-1-phosphate .1Sphinganine (d18:0) levels increase significantly in response to certain mycotoxins, including fumonisins, as well as in some cancers.2,3,4


1.Smith, E.R., and Merrill, A.H., Jr.Differential roles of de novo sphingolipid biosynthesis and turnover in the 'Burst' of free sphingosine and sphinganine, and their 1-phosphates and N-acyl-derivatives, that occurs upon changing the medium of cells in cultureJ. Biol. Chem.270(32)18749-18758(1995) 2.Pruett, S.T., Bushnev, A., Hagedorn, K., et al.Biodiversity of sphingoid bases ("sphingosines") and related amino alcoholsJ. Lipid Res.49(8)1621-1639(2008) 3.Shephard, G.S., van der Westhuizen, L., and Sewram, V.Biomarkers of exposure to fumonisin mycotoxins: A reviewFood Addit. Contam.24(10)1196-1201(2007) 4.Yin, J., Miyazaki, K., Shaner, R.L., et al.Altered sphingolipid metabolism induced by tumor hypoxia - new vistas in glycolipid tumor markersFEBS Lett.584(9)1872-1878(2010)