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5'-Thymidylic Acid(sodium salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
5'-Thymidylic Acid(sodium salt)图片
规格:98%
分子量:366.2
包装与价格:
包装价格(元)
100mg电议
250mg电议
1g电议

产品介绍
A deoxyribonucleotide
货号:ajcx24426
CAS:33430-62-5
分子式:C10H13N2O8P•2Na
分子量:366.2
溶解度:PBS (pH 7.2): slightly soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

5'-Thymidylic acid (dTMP) is a deoxyribonucleotide.1It is formedviamethylation of dUMP by thymidylate synthase. It is further phosphorylated by thymidine kinase (TK) to form dTDP during nucleic acid synthesis.2Oral administration of dTMP in combination with dCMP increases lifespan in aTk2 H126Nknock-in mouse model of TK2 deficiency.3


1.Berg, J.M., Tymoczko, J.L., and Stryer, L.Nucleotide BiosynthesisBiochemistry(2002) 2.Lee, L.S., and Cheng, Y.Human thymidylate kinase. Purification, characterization, and kinetic behavior of the thymidylate kinase derived from chronic myelocytic leukemiaJ. Biol. Chem.252(16)5686-5691(1977) 3.Lopez-Gomez, C., Levy, R.J., Sanchez-Quintero, M.J., et al.Deoxycytidine and deoxythymidine treatment for thymidine kinase 2 deficiencyAnn. Neurol.81(5)641-652(2017)