| 规格: | 98% |
| 分子量: | 272.4 |
| 包装 | 价格(元) |
| 500ug | 电议 |
| 1mg | 电议 |
| 5mg | 电议 |
Background:
Albendazole-d7is intended for use as an internal standard for the quantification of albendazole by GC- or LC-MS. Albendazole is an orally bioavailable benzimidazole anthelmintic that is active against a variety of helminths, including liver flukes, tapeworms, and roundworms.1It eliminatesTrichostrongylusin the fourth stomach of cattle and sheep when orally administered at doses ranging from 2.5 to 10 mg/kg as well as other species in the fourth stomach and the small and large intestine. Albendazole (0.05% in the diet) protects mice against lethal infection withA. suumlarvae. It also inhibits growth of HT-29 human colorectal cancer cells (IC50= 0.12 µM), halts the cell cycle at the G2/M phase, and induces apoptosis. In an HT-29 mouse xenograft model, it inhibits peritoneal tumor growth when administered intraperitoneally at a dose of 150 mg/kg but not when administered orally.2Albendazole inhibits mammalian tubulin polymerization and inhibits binding of [3H]mebendazole toH. contortusL3 larval tubulin (IC50s = 6.9 and 0.21 µM, respectively).3Formulations containing albendazole have been used in the treatment of tapeworm infections and in a variety of nematode infections in livestock and pets.
1.Theodorides, V.J., Gyurik, R.J., Kingsbury, W.D., et al.Anthelmintic activity of albendazole against liver flukes, tapeworms, lung and gastrointestinal roundwormsExperientia32(6)702-703(1976) 2.Pourgholami, M.H., Akhter, J., Wang, L., et al.Antitumor activity of albendazole against the human colorectal cancer cell line HT-29: In vitro and in a xenograft model of peritoneal carcinomatosisCancer Chemother. Pharmacol.55(5)425-432(2005) 3.Lacey, E.Mode of action of benzimidazolesParasitol. Today6(4)112-115(1990)
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