| 规格: | 98% |
| 分子量: | 252.3 |
| 包装 | 价格(元) |
| 1g | 电议 |
| 5g | 电议 |
| 10g | 电议 |
Background:
7-Methoxyflavone is a flavone that has been found inZ. brasiliensisand has diverse biological activities.1,2,3,4It inhibits aromatase (IC50= 1.9 µM in a cell-free assay) and LPS-induced nitric oxide (NO) production by 17.74% in RAW 264.7 macrophages when used at a concentration of 20 µM.1,27-Methoxyflavone activates androgen and/or glucocorticoid receptor transcriptional activity in a reporter assay and has antinociceptive effects in the acetic acid-induced writhing test in mice (ED50= 82.5 µmol/kg).3,4
1.Ta, N., and Walle, T.Aromatase inhibition by bioavailable methylated flavonesJ. Steroid. Biochem. Mol. Biol.107(1-2)127-129(2007) 2.An, J.-Y., Lee, H.-H., Shin, J.-S., et al.Identification and structure activity relationship of novel flavone derivatives that inhibit the production of nitric oxide and PGE2 in LPS-induced RAW 264.7 cellsBioorg. Med. Chem. Lett.27(11)2613-2616(2017) 3.Nishizaki, Y., Ishimoto, Y., Hotta, Y., et al.Effect of flavonoids on androgen and glucocorticoid receptors based on in vitro reporter gene assayBioorg. Med. Chem. Lett.19(16)4706-4710(2009) 4.da Silva, A.D.S., Cavalcante-Silva, L.H.A., da Matta, C.B.B., et al.Antinociceptive effect of 7-methoxyflavone isolated from Zornia brasiliensisNat. Prod. Res.27(18)1695-1699(2013)
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