A thiazole antibiotic
货号:ajcx25056
CAS:12656-40-5
分子式:C16H17N5O6S2
分子量：439.5
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Althiomycin is a polyketide synthase-derived thiazole antibiotic originally isolated fromS. althioticus.¹It is active against Gram-positive bacteria, includingS. aureus,S. epidermidis, andS. pyogenes(MICs = 25, 25, and 3.1 µg/ml, respectively).²Althiomycin inhibits protein synthesis inE. coliwhen used at concentrations of 1 and 10 µg/ml but not in isolated rabbit reticulocytes at 100 µg/ml.³

1.Gerc, A.J., Song, L., Challis, G.L., et al.The insect pathogen Serratia marcescens Db10 uses a hybrid non-ribosomal peptide synthetase-polyketide synthase to produce the antibiotic althiomycinPLoS One7(9)e44673(2012) 2.Inami, K., and Shiba, T.Syntheses of althiomycin analogs in relation to antibacterial activitiesBull. Chem. Soc. Jpn.59(7)2185-2189(1986) 3.Fujimoto, H., Kinoshita, T., Suzuki, H., et al.Studies on the mode of action of althiomycinJ. Antibiot. (Tokyo)23(6)271-275(1970)