An internal standard for the quantification of loxapine
货号:ajcx25128
CAS:1189455-63-7
分子式:C18H10ClD8N3O
分子量：335.9
溶解度:Acetonitrile: soluble,DMSO: soluble,Methanol: soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Loxapine-d₈is intended for use as an internal standard for the quantification of loxapine by GC- or LC-MS. Loxapine is an atypical antipsychotic.¹It binds to the serotonin (5-HT) receptor subtypes 5-HT_1A, 5-HT_2A, 5-HT_2C, 5-HT₆, and 5-HT₇(K_is = 2,456, 7.7, 9.5, 32, and 87.2 nM, respectively), as well as dopamine D₂, histamine H₁, and M₃muscarinic acetylcholine receptors (K_is = 12, 7, and 122 nM, respectively). Loxapine also binds to α_1A-, α_2A-, α_2B-, and α_2C-adrenergic receptors (K_is = 31, 150.8, 107.6, and 79.9 nM, respectively). Formulations containing loxapine have been used in the treatment of schizophrenia.

1.Kroeze, W.K., Hufeisen, S.J., Popadak, B.A., et al.H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugsNeuropsychopharmacology28(3)519-526(2003)