An internal standard for the quantification of phenylbutazone
货号:ajcx25234
CAS:1189479-75-1
分子式:C19H11D9N2O2
分子量：317.4
溶解度:Methanol: soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Phenylbutazone-d₉is intended for use as an internal standard for the quantification of phenylbutazone by GC- or LC-MS. Phenylbutazone is a non-steroidal anti-inflammatory drug and an inhibitor of the peroxidase activity of COX (IC₅₀= ~100 µM in the presence of hydrogen peroxide).¹It also inhibits prostaglandin I synthase (IC₅₀= ~25 µM in the presence of hydrogen peroxide). Phenylbutazone (2 mg/kg) reduces increases in type II collagen levels in the inflamed joints of an equine model of LPS-induced acute synovitis.²Formulations containing phenylbutazone have been used in the treatment of lameness in horses.

1.Reed, G.A., Griffin, I.O., and Eling, T.E.Inactivation of prostaglandin H synthase and prostacyclin synthase by phenylbutazone. Requirement for peroxidative metabolismMol. Pharmacol.27(1)109-114(1985) 2.de Grauw, J.C., van Loon, J.P.A.M., van de Lest, C.H.A., et al.In vivo effects of phenylbutazone on inflammation and cartilage-derived biomarkers in equine joints with acute synovitisVet. J.201(1)51-56(2014)