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Fluvoxamine-d4(maleate)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Fluvoxamine-d4(maleate)图片
规格:98%
分子量:438.4
包装与价格:
包装价格(元)
500ug电议
1mg电议
5mg电议

产品介绍
An internal standard for the quantification of fluvoxamine
货号:ajcx25750
CAS:N/A
分子式:C15H17D4F3N2O2·C4H4O4
分子量:438.4
溶解度:Water: soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Fluvoxamine-d4is intended for use as an internal standard for the quantification of fluvoxamine by GC- or LC-MS. Fluvoxamine is a selective serotonin reuptake inhibitor (SSRI).1It selectively inhibits reuptake of serotonin over norepinephrine reuptake in rat hypothalamic synaptosomes (Kis = 6.2 and 1,100 nM, respectively). Fluvoxamine (10 mg/kg) reduces immobility time in the forced swim test in mice, an effect that can be blocked by the sigma-1 (σ1) receptor antagonist BD 1047 .2It also reduces marble-burying behavior in the marble-burying test in mice when administered at a dose of 45 mg/kg, indicating anxiolytic- or reduced obsessive compulsive-like behaviors.3Formulations containing fluvoxamine have been used in the treatment of obsessive compulsive disorder and social anxiety disorder.


1.Johnson, A.M.An overview of the animal pharmacology of paroxetineActa Psychiatr. Scand.80(Suppl. 350)14-20(1989) 2.Sugimoto, Y., Tagawa, N., Kobayashi, Y., et al.Involvement of the sigma1 receptor in the antidepressant-like effects of fluvoxamine in the forced swimming test in comparison with the effects elicited by paroxetineEur. J. Pharmacol.696(1-3)96-100(2012) 3.Hayashi, A., Yamashita, N., Baba, J., et al.Effects of co-administered fluvoxamine and diazepam, ethyl loflazepate or imipramine on marble-burying behavior in miceOyo Yakuri57(5-6)103-108(1999)