规格: | 98% |
分子量: | 2006.3 |
包装 | 价格(元) |
1mg | 电议 |
5mg | 电议 |
Background:
BQ-3020 is a peptide endothelin type B (ETB) receptor agonist.1It selectively binds to ETBover ETAreceptors (IC50s = 0.07 and 940 nM, respectively) and induces inositol triphosphate formation and calcium mobilization in isolated bovine carotid artery endothelial cells.1,2BQ-3020 increases or decreases renal perfusion pressure in Dahl salt-resistant or -sensitive rats, respectively.3It decreases the production of nitric oxide (NO) and induces vasoconstriction in a rat model of diet-induced hypercholesterolemia.
1.Ihara, M., Saek, T., Fukuroda, T., et al.A novel radioligand [125I]BQ-3020 selective for endothelin (ETB) receptorsLife Sci.51(6)PL47-PL52(1992) 2.Hirata, Y., Emori, T., Eguchi, S., et al.Endothelin receptor subtype B mediates synthesis of nitric oxide by cultured bovine endothelial cellsJ. Clin. Invest.91(4)1367-1373(1993) 3.Kakoki, M., Hirata, Y., Hayakawa, H., et al.Effects of hypertension, diabetes mellitus, and hypercholesterolemia on endothelin type B receptor-mediated nitric oxide release from rat kidneyCirculation99(9)1242-1248(1999)