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Z 944
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Z 944图片
规格:98%
分子量:383.89
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
Z 944 是一种口服活性 T 型钙通道拮抗剂,可挽救交叉模式和视觉识别记忆的损伤。
货号:ajcx27552
CAS:1199236-64-0
分子式:C19H27ClFN3O2
分子量:383.89
溶解度:Chloroform: soluble,Methanol: soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Selective T-type Ca2+ channel blocker (IC50 values are 50 to 160 nM for hCav3.1, hCav3.2 and hCav3.3). Exhibits 50 to 600 fold selectivity for Cav3.x channels over related ion channels (Cav1.2, hERG and Nav1.5). Has no effect on action potential properties in isolated heart Purkinje fibers and no adverse effects on ECG parameters in vivo. Exhibits anti-seizure effects in animal models.


Tringham et al (2012) T-type calcium channel blockers that attenuate thalamic burst firing and suppress absence seizures. Sci.Transl.Med. 4 121 PMID:22344687 |Casillas-Espinosa et al (2015) Z944, a novel selective T-type calcium channel antagonist delays the progression of seizures in the amygdala kindling model. PLoS One. 10 e0130012 PMID:26274319