NNMTi 是一种有效的烟酰胺 N-甲基转移酶 (NNMT) 抑制剂 (IC50=1.2 μM)，可选择性结合 NNMT 底物结合位点残基。
货号:ajcx27876
CAS:42464-96-0
分子式:C10H11IN2
分子量：286.11
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Nicotinamide N-methyltransferase (NNMT) inhibitor (IC50 = 1.2 μM). Promotes myoblast differentiation in C2C12 cells. Activates senescent muscle stem cells (muSCs) and improves regenerative capacity of aged skeletal muscle. Enhances proliferation, fusion and regenerative capacity of muSCs in aged mice.

Neelakantan et al (2019) Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle. Biochem. Pharmacol. 163 481 PMID:30753815 |Neelakantan et al (2017) Structure-activity relationship for small molecule inhibitors of nicotinamide N-methyltransferase. J.Med.Chem. 60 5015 PMID:28548833