An antimicrobial peptide
货号:ajcx28432
CAS:172820-23-4
分子式:C122H210N32O22 ? XC2H4O2
分子量：2477.2
溶解度:DMF: Slightly soluble,DMSO: Slightly soluble,Ethanol: 12 mg/ml,PBS (pH 7.2): 5 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Pexiganan is a synthetic antimicrobial peptide.¹It is active against various clinical isolates of bacteria from patients with diabetic foot infections, includingS. aureus, methicillin-resistantS. aureus(MRSA), andP. aeruginosa(MICs = 16-32, 16-32, and 8-16 µg/ml, respectively). Pexiganan (1 mg/kg) decreases lethality in a mouse model of sepsis induced byA. baumannii.²

1.Flamm, R.K., Rhomberg, P.R., Simpson, K.M., et al.In vitro spectrum of pexiganan activity when tested against pathogens from diabetic foot infections and with selected resistance mechanismsAntimicrob. Agents Chemother.59(3)1751-1754(2015) 2.Cirioni, O., Simonetti, O., Pierpaoli, E., et al.Enhanced efficacy of combinations of pexiganan with colistin versus Acinetobacter Baumannii in experimental sepsisShock46(2)219-225(2016)