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QD325
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:2132410-88-7
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
50mg电议
500mg电议

产品介绍

QD325 is a potent redox modulator for the Treatment of Pancreatic Ductal Adenocarcinoma. QD325 can induce substantial reactive oxygen species (ROS) in PDAC cells. Nascent RNA sequencing following treatments with QD325 revealed induction of stress responses in nucleus, endoplasmic reticulum, and mitochondria of pancreatic cancer cells. Furthermore, QD325 induced Nrf2-mediated oxidative stress and unfolded protein responses as demonstrated by dose dependent increases in RNA synthesis of representative genes such as NQO1, HMOX1, DDIT3 and HSPA5. QD325 is as a new therapeutic in the treatment of PDAC. References: Kuang Y, Sechi M, Nurra S, Ljungman M, Neamati N. Design and Synthesis of Novel Reactive Oxygen Species Inducers for the Treatment of Pancreatic Ductal Adenocarcinoma. J Med Chem. 2018 Jan 12. doi: 10.1021/acs.jmedchem.7b01463. [Epub ahead of print] PubMed PMID: 29328656.

纯度:≥98%

CAS:2132410-88-7