Anti-virusagent1(compound4i)是GS-5734的氨基磷酸酯前药，具有有效的抗病毒(antiviral)活性。Anti-virusagent1用于冠状病毒和埃博拉病毒(EBOV)的研究。
货号:ajcx30170
CAS:1911578-83-0
分子式:C24H29N6O8P
分子量：560.5
溶解度:DMSO: 200 mg/mL (356.82 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Anti-virus agent 1 (compound 4i), a phosphoramidate prodrug of GS-5734 , has potent antiviral activity. Anti-virus agent 1 is used for the research of coronavirus and Ebola virus (EBOV)[1][2].

Anti-virus agent 1 (compound 4i) has antiviral activity for EBOV in HeLa cell (EC50=1845 nM), HMVEC cell (TERT-immortalized human foreskin microvascular endothelial cells; ATCC-4025; EC50=367 nM), human macrophages (EC50=297 nM). Anti-virus agent 1 has a CC50 of 21 μM in MT4 cell (human leukemia T-cell)[1].

[1]. Dustin Siegel , et al. Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses. J Med Chem. 2017 Mar 9;60(5):1648-1661. [2]. Michael O' Neil Hanrahan Clarke, et al.Methods for treating arenaviridae and coronaviridae virus infections. US20170071964A1.