BIO-11006acetate，MANS肽的类似物，是一种MARCKS(myristoylatedalanine-richCkinasesubstrate)抑制剂。
货号:ajcx30278
CAS:N/A
分子式:C48H79N13O17
分子量：1110.22
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

BIO-11006 acetate, an analog of the MANS peptide, is a MARCKS (myristoylated alanine-rich C kinase substrate) inhibitor[1].

Inhaled, aerosolized BIO-11006 acetate attenuates LPS-induced neutrophil influx into the lung, activation of NF-κB, and expression of the proinflammatory cytokines, KC and TNF-α, and thus reverses the development of lung injury in mice instilled intratracheally with LPS[1].

[1]. Yin Q, et al. An Inhaled Inhibitor of Myristoylated Alanine-Rich C Kinase Substrate Reverses LPS-Induced Acute Lung Injury in Mice. Am J Respir Cell Mol Biol. 2016 Nov;55(5):617-622.