Chlorphenesin是一种可逆的抗原相关免疫抑制剂。Chlorphenesin是一种抗菌和抗真菌剂，用于许多眼保健化妆品中。
货号:ajcx30390
CAS:104-29-0
分子式:C9H11ClO3
分子量：202.63
溶解度:DMSO: 100 mg/mL (493.51 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Chlorphenesin is a reversible antigen-associated immunosuppressant. Chlorphenesin is an antibacterial and antifungal agent used in numerous eye care cosmetics[1].

Chlorphenesin (0.01, 0.1, 0.3%; 30-min exposure) significantly reduces the activity of the Akt pathway in a dose-dependent manner in human meibomian gland epithelial cells (HMGECs)[2]. Chlorphenesin (0.1, 0.3%; 24 hours) induces immortalized HMGECs (IHMGECs) rounding, atrophy, poor adherence, detachme and significantly reduces the number of IHMGECs[2].

[1]. H Y Whang, et al. Chlorphenesin: an antigen-associated immunosuppressant. Infect Immun. 1970 Jul;2(1):60-4. [2]. Jingyi Wang, et al. Toxicity of the cosmetic preservatives parabens, phenoxyethanol and chlorphenesin on human meibomian gland epithelial cells. Exp Eye Res. 2020 Jul;196:108057.