TRC-766是一种RTC-5(TRC-382)的阴性对照。TRC-766可结合蛋白磷酸酶2A(PP2A)，但不激活磷酸酶。
货号:ajcx31602
CAS:1810734-44-1
分子式:C25H24ClF3N2O3S
分子量：524.98
溶解度:DMSO: 150 mg/mL (285.73 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

TRC-766 is a negative control of RTC-5 (TRC-382). TRC-766 binds protein phosphatase 2A (PP2A) and does not activate the phosphatase[1].

As a pharmacologic control, the cells are treated with increasing doses of TRC-766, which is structurally similar to PP2A (SMAP) but biologically inactive. TRC-766 lacks a key N-H sulfonamide hydrogen bond donor. While TRC-766 still binds PP2A, it does not activate the phosphatase and therefore it was postulated to not affect cell viability[1].

[1]. Kimberly McClinch, et al. Small-Molecule Activators of Protein Phosphatase 2A for the Treatment of Castration-Resistant Prostate Cancer. Cancer Res. 2018 Apr 15;78(8):2065-2080.