AG-636 是一种有效，可逆，选择性和具有口服活性的二氢乳清酸脱氢酶 (DHODH) 抑制剂，IC50 为 17 nM。AG-636 具有很强的抗癌作用。
货号:ajcx33784
CAS:1623416-31-8
分子式:C21H17N3O2
分子量：343.38
溶解度:DMSO : 31.25 mg/mL (91.01 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

AG-636 is a potent, reversible, selective and orally active dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 17 nM. AG-636 has strong anticancer effects[1].

AG-636 has strong growth-inhibitory activity in cancer cell lines of hematologic versus solid tumor origin[1].

AG-636 (10-100 mg/kg ; oral gavage; twice daily; for 14 days) treatment results in robust tumor growth inhibition in the OCILY19 DLBCL tumor xenograft model[1].

[1]. Gabrielle McDonald, et al. Selective Vulnerability to Pyrimidine Starvation in Hematologic Malignancies Revealed by AG-636, a Novel Clinical-Stage Inhibitor of Dihydroorotate Dehydrogenase. Mol Cancer Ther. 2020 Dec;19(12):2502-2515.