RU-302 是一种非选择性的TAM 抑制剂，阻断 TAM Ig1 胞外域和 Gas6 Lg 结构域之间的界面。RU-302 用低微摩尔 IC50 有效阻断 Gas6 诱导的 Axl 受体活化，并有效抑制肺癌肿瘤的生长。
货号:ajcx37510
CAS:1182129-77-6
分子式:C24H24F3N3O2S
分子量：475.53
溶解度:DMSO : 100 mg/mL (210.29 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

RU-302 is a pan TAM inhibitor that blocks the interface between the TAM Ig1 ectodomain and the Gas6 Lg domain. RU-302 effectively blocks Gas6-inducible Axl receptor activation with a low micromolar IC50in cell assays, and suppresses lung cancer tumor growth[1].

[1]. Kimani SG, et al. Small molecule inhibitors block Gas6-inducible TAM activation and tumorigenicity. Sci Rep. 2017 Mar 8;7:43908.