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KB-5492 free base
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
KB-5492 free base图片
规格:98%
分子量:430.49
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
KB-5492 free base 是一种有效的和选择性的 sigma 受体抑制剂,抑制 [3H]1,3-di(2-tolyl)guanidine (DTG) 与 sigma 受体结合,IC50 值为 3.15 μM。KB-5492 free base 是一种抗溃疡剂。
货号:ajcx39070
CAS:113594-64-2
分子式:C23H30N2O6
分子量:430.49
溶解度:DMSO : 100 mg/mL (232.29 mM; Need ultrasonic)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

KB-5492 free base is a potent and selective inhibitor of sigma receptor, inhibits specific [3H]1,3-di(2-tolyl)guanidine (DTG) binding to the sigma receptor with an IC50 of 3.15 μM. KB-5492 free base is an anti-ulcer agent[1][2].

KB-5492 (0.001-100 μM) free base inhibits specific [3H]DTG binding in a concentration-dependent manner[1].KB-5492 (0.1-1 mM) free base significantly and concentration-dependently prevents the ethanol- and acidified aspirin-induced increases in 51Cr release from gastric epithelial cells[2].

KB-5492 (200 mg/kg; p.o.) free base prevents macroscopic lesions in the gastric mucosa[2].

[1]. Harada Y, et, al. Receptor binding profiles of KB-5492, a novel anti-ulcer agent, at sigma receptors in guinea-pig brain. Eur J Pharmacol. 1994 May 2; 256(3): 321-8.
[2]. Morimoto Y, et, al. Effects of KB-5492, a new anti-ulcer agent, on ethanol- and acidified aspirin-induced gastric mucosal damage in vivo and in vitro. Jpn J Pharmacol. 1994 Jan; 64(1): 41-7.