Envonalkib 是一种有效和具有口服活性的 ALK 抑制剂，抑制 WT 和突变的 L1196M 和 G1269S-ALK 的 IC50 值分别为 1.96 nM，35.1 nM 和 61.3 nM。Envonalkib 可用于非小细胞肺癌的研究。
货号:ajcx39466
CAS:1621519-26-3
分子式:C24H26Cl2FN5O2
分子量：506.4
溶解度:DMSO : 100 mg/mL (197.47 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Envonalkib is a potent and orally active inhibitor of ALK, with IC50s of 1.96 nM, 35.1 nM, and 61.3 nM for WT and mutated L1196M and G1269S-ALK. Envonalkib can be used for the research of non-small cell lung cancer[1].

Envonalkib (formula I) (12.5-25 mg/kg; p.o. once daily for 14 days) inhibits the growth of human non-small cell lung cancer NCI-H2228 nude mice xenografts[1].

[1]. Feng G, et, al. Pyridine-substituted 2-aminopyridine protein kinase inhibitors. WO2016015676A1.