LDC7559 是一种 消皮素 D (GSDMD) 的抑制剂，通过抑制中性粒细胞胞外杀菌网络 (NET) 后期阶段而发挥作用。
货号:ajcx39492
CAS:2407782-01-6
分子式:C20H19N3O3
分子量：349.38
溶解度:DMSO : ≥ 125 mg/mL (357.78 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

LDC7559 is a gasdermin D (GSDMD) inhibitor via blocking neutrophil extracellular trap (NET) in the late stages [1].

LDC7559 (1 and 5 μM) inhibits IL-1β release upon inflammasome activation, and significantly blocks the lethal effect of both human and murine GSDMD NT domains transfected into HEK293T cells[3].LDC7559 functions directly through blocking the activity of the GSDMD NT domain, rather than interfering with the activation and cleavage process[3].

[1]. Spel L, et al. Gasdermin D opens the way for NETs. Nat Rev Rheumatol. 2018 Dec;14(12):690-692.
[2]. Sollberger G, et al. Gasdermin D plays a vital role in the generation of neutrophil extracellular traps. Sci Immunol. 2018 Aug 24;3(26). pii: eaar6689.
[3]. Ankit Pandeya, et al. Gasdermin D (GSDMD) as a New Target for the Treatment of Infection. Medchemcomm. 2019 Apr 4;10(5):660-667.