TVB-3664 是具有口服活性的、可逆的、有效的、选择性的并具有高生物利用度的脂肪酸合酶 (FASN)?抑制剂，其对人和老鼠棕榈酸酯合成的?IC50?值分别为 18 nM 和 12 nM。可显著降低微管蛋白棕榈酰化和 mRNA表达。
货号:ajcx12312
CAS:2097262-58-1
分子式:C25H23F3N4O2
分子量：468.47
溶解度:DMSO : 10 mg/mL (21.35 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

TVB-3664 is an orally available, reversible, potent, selective and highly bioavailable?fatty acid synthase (FASN)?inhibitor, with?IC₅₀?values of 18 nM and 12 nM for human and mouse cell palmitate synthesis, respectively. TVB-3664 significantly reduces tubulin palmitoylation and mRNA expression^[1][2].