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AR-A 2(AR-A 000002)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AR-A 2(AR-A 000002)图片
规格:98%
分子量:448.6
包装与价格:
包装价格(元)
250mg电议
500mg电议

产品介绍
AR-A2是一种选择性的5-HT1Breceptor拮抗剂,对豚鼠皮层5HT1B/1D受体有很高的亲和性,Ki值为0.24nM,对豚鼠5-HT1B受体的Ki值为0.47nM,EC50值为4.5nM,对豚鼠5-HT1D
货号:ajcx12562
CAS:220051-79-6
分子式:C27H36N4O2
分子量:448.6
溶解度:Soluble in DMSO
纯度:98%
存储:Store at -20°C
库存:现货

Background:

AR-A 2 is a selective 5-HT1B receptor antagonist, with high affinity to guinea pig cortex 5HT1B/1D and recombinant guinea pig 5-HT1B receptors (Ki=0.24 and 0.47 nM) and with 10-fold lower affinity to guinea pig 5-HT1D receptor (Ki, 5 nM), and shows an EC50 of 4.5 nM for the guinea pig 5-HT1B receptor; AR-A 2 can be used in the research of depression and anxiety.

AR-A 2 (AR-A000002) is a selective 5-HT1B receptor antagonist, with high affinity to guinea pig cortex 5HT1B/1D and recombinant guinea pig 5-HT1B receptors (Ki=0.24 and 0.47 nM) and with 10-fold lower affinity to guinea pig 5-HT1D receptors (Ki, 5 nM), and shows an EC50 of 4.5 nM for the guinea pig 5-HT1B receptor. AR-A 2 also binds to the rat cortical 5HT1B/1D receptor (Ki, 20 nM), rat cortex 5-HT2A receptor (Ki, 339 nM), rat hippocampus 5-HT1A receptor (Ki, 3070 nM). In addition, AR-A 2 also exhibits affinity for dopamine D2 (Ki, 330 nM) and α1-adrenoceptors (Ki, 490 nM)[1].


[1]. Ahlgren C, et al. In vitro characterization of AR-A000002, a novel 5-hydroxytryptamine(1B) autoreceptor antagonist. Eur J Pharmacol. 2004 Sep 19;499(1-2):67-75.