Amelubant(BIIL284)是一种有效、可口服、长效的LTB4receptor拮抗剂，对LTB4受体的结合亲和性很低，在细胞和细胞膜中，Ki值分别为221nM和230nM。Amelubant(BIIL284)是活性代谢物BIIL260和BIIL315的前体。具有抗炎活性。
货号:ajcx12752
CAS:346735-24-8
分子式:C33H34N2O5
分子量：538.63
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Amelubant (BIIL 284) is a potent, oral and long acting LTB4 receptor antagonist, negligibly binds to LTB4 receptor, with Kis of 221 nM and 230 nM in vital cells and membranes. Amelubant (BIIL 284) is a prodrug of active metabolites BIIL 260 and BIIL 315. Anti-inflammatory activity[1].

Amelubant is a prodrug of active metabolites BIIL 260 and BIIL 315, which are reversible and competitive LTB4 receptor antagonists, with Kis of 1.4, 1.1 nM and 1.7, 1.9 nM in vital cells and membranes, respectively[1].

[1]. Birke FW, et al. In vitro and in vivo pharmacological characterization of BIIL 284, a novel and potent leukotriene B(4) receptor antagonist. J Pharmacol Exp Ther. 2001 Apr;297(1):458-66.