Bimosiamose是一种广谱的选择素selectin拮抗剂，能够抑制E-，P-和L-selectin的活性，IC50分别为88μM，20μM和86μM，可用于炎症的研究。
货号:ajcx13110
CAS:187269-40-5
分子式:C46H54O16
分子量：862.91
溶解度:DMSO: 125 mg/mL (144.86 mM); 0.1 M NaOH: 25 mg/mL (28.97 mM; ultrasonic and adjust pH to 10 with NaOH)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Bimosiamose is a pan-selectin antagonist, inhibits E-, P-, and L-selectin with IC50s of 88 μM, 20 μM, and 86 μM, respectively, and can be used in the research of inflammatory disease.

Bimosiamose is a pan-selectin antagonist, inhibits E-, P-, and L-selectin with IC50s of 88 μM, 20 μM, and 86 μM, respectively, and can be used in the research of inflammatory disease[1].

Bimosiamose (25 mg/kg, i.v.) significantly improves the survival in rats subjected to severe hepatic ischemia and reperfusion. Bimosiamose also causes lower ALT enzyme levels and decreases neutrophil infiltration[1].

[1]. Palma-Vargas JM, et al. Small-molecule selectin inhibitor protects against liver inflammatory response after ischemia and reperfusion. J Am Coll Surg. 1997 Oct;185(4):365-72.