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DO-264
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
DO-264图片
规格:98%
分子量:558.4
包装与价格:
包装价格(元)
250mg电议
500mg电议

产品介绍
DO-264是一个具有体内活性的、自水解酶结构域12(ABHD12)的抑制剂,其IC50值为11nM。
货号:ajcx13380
CAS:2301866-59-9
分子式:C23H20Cl2F3N5O2S
分子量:558.4
溶解度:DMSO : ≥ 100 mg/mL (179.08 mM);H2O :< 0.1 mg/mL (insoluble)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

DO-264 is a selective and in vivo-active inhibitor of Abhydrolase Domain Containing 12 (ABHD12), with an IC50 of 11 nM.

DO-264 displays an IC50 value of 11 nM (9.6 nM-13 nM). DO-264 blocks lyso-PS hydrolysis activities of recombinant mouse and human ABHD12 in transfected HEK293T cell lysates (DO-264 IC50 values of ~30 and 90 nM against mouse and human ABHD12, respectively) and the ABHD12-dependent lyso-PS lipase activity of membrane lysates from mouse brain (IC50=2.8 nM, 2.4 nM-3.3 nM) and human THP-1 cells (IC50= 8.6 nM, 6.3 nM-12 nM)[1].

Mice treated with DO-264 display dose-dependent increases in brain lyso-PS and 20:4 PS content that are qualitatively similar to the changes observed in ABHD12-/- mice. DO-264-treated mice, however, show minimal impairment in auditory function following four weeks of drug exposure. Both ABHD12-/- and DO-264-treated mice display exacerbated immunopathology following infection with the lymphocytic choriomeningitis virus (LCMV) clone 13, resulting in severe inflammatory lung damage, heightened chemokine production, and, in some cases, death[1].

[1]. Ogasawara D, et al. Selective blockade of the lyso-PS lipase ABHD12 stimulates immune responses in vivo. Nat Chem Biol. 2018 Dec;14(12):1099-1108.