PF-06928215是一种高亲和力的cGAS(cyclicGMP-AMPSynthase)抑制剂，IC50为4.9μμ，亲和力为0.2μμ(KD)。
货号:ajcx13610
CAS:2378173-15-8
分子式:C20H20N4O4
分子量：380.4
溶解度:DMSO : 33.33 mg/mL (87.62 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

PF-06928215 is a cGAS (cyclic GMP-AMP Synthase) inhibitor with an IC50 of 4.9 μμ. PF-06928215 has a high binding affinity of 0.2 μM (KD)[1]. IC50: 4.9 μM (cGAS)[1]

[1]. Hall J, et al. Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay. PLoS One. 2017 Sep 21;12(9):e0184843.