LX-1031 is a THP inhibitor (a tryptophan 5-hydroxylase inhibitor) that reduces 5-HT levels for the potential treatment of irritable bowel syndrome. LX-1031 has potential for illnesses characterized by excess 5-HT, such as diarrhea-predominant irritable bowel syndrome (IBS-D) and carcinoid diarrhea. In vitro, inhibition of TPH1 occurred in 10(-8) -10(-7) mol L(-1) range. In vivo in rodents, LX-1031 has no effect on brain 5-HT while dose-dependently reducing 5-HT, particularly in the small bowel. References: Camilleri M. LX-1031, a tryptophan 5-hydroxylase inhibitor, and its potential in chronic diarrhea associated with increased serotonin. Neurogastroenterol Motil. 2011 Mar;23(3):193-200. doi: 10.1111/j.1365-2982.2010.01643.x. Epub 2010 Dec 15. Review. PubMed PMID: 21159063; PubMed Central PMCID: PMC3076306.

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CAS：945976-76-1