Lidoflazine 是 HERG K+ 通道的高亲和力阻滞剂。Lidoflazine 也是一种抗心绞痛的钙通道阻滞剂，具有延长 QT 间期和发生室性心律失常的重大风险。
货号:ajcx14930
CAS:3416-26-0
分子式:C30H35F2N3O
分子量：491.62
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Lidoflazine is a high affinity blocker of the HERG (human ether-a-go-go-related gene) K+ channel. Lidoflazine is an antianginal calcium channel blocker that carries a significant risk of QT interval prolongation and ventricular arrhythmia[1].

Lidoflazine inhibits potently HERG current (IHERG) recorded from HEK 293 cells stably expressing wild-type HERG (IC50 of ~16 nM).

[1]. https://www.ncbi.nlm.nih.gov/pubmed/15135665