Luzindole, formerly known as N-0774, and N-acetyl-2-benzyltryptamine, is a drug used in scientific research to study the role of melatonin in the body. Luzindole acts as a selective melatonin receptor antagonist, with approximately 11- to 25-fold greater affinity for the MT2 over the MT1 receptor. In animal studies, it has been observed to disrupt the circadian rhythm as well as produce antidepressant effects. References: Juszczak M, Roszczyk M, Kowalczyk E, Stempniak B. The influence od melatonin receptors antagonists, luzindole and 4-phenyl-2-propionamidotetralin (4-P-PDOT), on melatonin-dependent vasopressin and adrenocorticotropic hormone (ACTH) release from the rat hypothalamo-hypophysial system. In vitro and in vivo studies. J Physiol Pharmacol. 2014 Dec;65(6):777-84. PubMed PMID: 25554981.

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CAS：117946-91-5