VBIT-4 是一种电压依赖性阴离子通道 (VDAC1) 低聚物抑制剂，Kd 为 17 μM。VBIT-4，作为细胞凋亡 (apoptosis) 抑制剂，用于治疗与细胞凋亡相关的疾病，例如神经退行性疾病和心血管疾病等。
货号:ajcx16110
CAS:2086257-77-2
分子式:C21H23ClF3N3O3
分子量：457.87
溶解度:DMSO: 125 mg/mL (273.00 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

VBIT-4 is an inhibitor of voltage-dependent anion channel 1 (VDAC1) oligomerization with a binding affinity (Kd) of 17 μM. VBIT-4, as an apoptosis inhibitor, can be used for therapeutic purposes in apoptosis-associated disorders, such as neurodegenerative and cardiovascular diseases[1].

[1]. Ben-Hail D, et al. Novel Compounds Targeting the Mitochondrial Protein VDAC1 Inhibit Apoptosis and Protect against Mitochondrial Dysfunction. J Biol Chem. 2016 Nov 25;291(48):24986-25003.