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Ramelteon-d5
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ramelteon-d5图片
规格:98%
分子量:264.4
包装与价格:
包装价格(元)
500ug电议
1mg电议

产品介绍
Ramelteon-d5 is intended for use as an internal standard for the quantification of ramelteon by GC- or LC-MS.
货号:ajcx17542
CAS:N/A
分子式:C16H16D5NO2
分子量:264.4
溶解度:Methanol: Soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Ramelteon-d5 is intended for use as an internal standard for the quantification of ramelteon by GC- or LC-MS. Ramelteon is a melatonin (MT) receptor agonist (Kis = 14, 112, and 23.1 pM for human MT1, human MT2, and chick forebrain receptors, respectively). It is selective for MT1 and MT2 over MT3 receptors (Ki = 2.65 μM for hamster brain MT3 receptors) as well as a panel of benzodiazepine, dopamine, and opiate receptors, ion channels, transporters, and enzymes when used at a concentration of 10 μM. Ramelteon stimulates cAMP production in CHO cells expressing human MT1 and MT2 receptors (IC50s = 21.2 and 53.4 pM, respectively). In vivo, ramelteon (0.03 and 0.3 mg/kg, p.o.) shortens latency to sleep onset and increases duration of sleep in free-moving crab-eating macaques. It also accelerates reentrainment of circadian rhythm in rats, shifting running wheel activity back to the dark period 2.4 and 3 days more quickly than vehicle-treated animals following an eight-hour phase shift in the light-dark cycle when administered at 0.1 and 1 mg/kg, respectively, with no effect on learning and memory in the Morris water maze and delayed match-to-position tasks.