| 包装: | 1mg |
| 规格: | 98% |
| 市场价: | 1272元 |
| 分子量: | 817 |
Background:
Neurotensin (8-13) is a neuropeptide that corresponds to the C-terminal residues 8-13 of neurotensin that binds to rat synaptic membranes with a Ki value of 13 nM. It induces contraction of guinea pig ileum (EC50 = 25 nM) and induces contraction of rat fundus equipotently to full length neurotensin (EC50s = 1.29 and 1.58 nM, respectively). In vivo, neurotensin (8-13) has antinociceptive effects in a mouse tail pressure test (ED50 = 50 nmol per animal). It induces extracellular dopamine release in the prefrontal cortex in rats. Neurotensin (8-13) also decreases diastolic blood pressure in a dose-dependent manner in normotensive rats without affecting heart rate.
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