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Urotensin II(human)(trifluoroacetate salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Urotensin II(human)(trifluoroacetate salt)图片
包装:1mg
规格:98%
市场价:2678元
分子量:1388.6

产品介绍
Urotensin II is a somatostatin-like neuropeptide agonist of the urotensin II receptor (UTR; Ki = 2 nM).
货号:ajcx19050
CAS:N/A
分子式:C64H85N13O18S2•XCF3COOH
分子量:1388.6
溶解度:Formic Acid: 1 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Urotensin II is a somatostatin-like neuropeptide agonist of the urotensin II receptor (UTR; Ki = 2 nM). It increases intracellular calcium levels in a concentration-dependent manner in HEK293 cells expressing human UTR (EC50 = 0.6 nM). Urotensin II increases the level of reactive oxygen species (ROS) in pulmonary artery smooth muscle cells and induces proliferation, an effect that is inhibited by depletion of NADPH oxidase subunits. Urotensin II potently induces contraction of isolated rat thoracic aorta with an EC50 of 0.8 nM. It also induces contraction of isolated cynomolgus monkey arterial, but not venous, vessels and, when administered at doses greater than 100 pmol/kg, can lead to severe myocardial depression and fatal circulatory collapse.