C4H3ClN2O2
货号:ajcx19266
CAS:1820-81-1
分子式:C4H3ClN2O2
分子量：146.5
溶解度:DMF: 8 mg/ml,DMSO: 0.8 mg/ml,Ethanol: 53 mg/ml,PBS (pH 7.2): 60 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

5-Chlorouracil is a chlorinated derivative of the pyrimidine nucleoside base uracil . In vivo, it is converted into chlorodeoxyuridine, which is mutagenic and genotoxic.1 Uracil is chlorinated at the 5 position in a cell-free myeloperoxidase, peroxide, and chloride system in which hypochlorous acid is formed.2 5-Chlorouracil has been found in human neutrophils stimulated with phorbol 12-myristate 13-acetate in vitro and in inflammatory human exudate isolated from sites of superficial infection. Levels of 5-chlorouracil are increased in exudate isolated from the site of inflammation in a rat model of carrageenan-induced inflammation and in patient-derived human atherosclerotic aortic tissue.3,4

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