A neuropeptide with diverse biological activities
货号:ajcx19832
CAS:N/A
分子式:C31H40N8O9.XHCl
分子量：668.7
溶解度:DMF: 20mg/mL,DMSO: 3mg/mL,PBS (pH 7.2): 3mg/mL
纯度：98%
存储：Store at -20°C
库存：现货

Background:

MeO-Suc-RPY-pNA is a colorimetric substrate for serine proteases, including trypsin, chymotrypsin, kallikrein-related peptidase 7 (KLK7), and kallikrein-related peptidase 3/prostate-specific antigen.1,2,3 Serine proteases preferentially bind to and cleave the Arg-Pro-Tyr (RPY) peptide sequence to release p-nitroanilide (pNA), which can be quantified by colorimetric detection at 405 nm as a measure of serine protease activity.

|2. de Veer, S.J., Furio, L., Swedberg, J.E., et al. Selective substrates and inhibitors for kallikrein-related peptidase 7 (KLK7) shed light on KLK proteolytic activity in the stratum corneum. J. Invest. Dermatol. 137(2), 430-439 (2017).|3. Clark, M.R., Aliyar, H.A., Lee, C.W., et al. Enzymatic triggered release of an HIV-1 entry inhibitor from prostate specific antigen degradable microparticles. Int. J. Pharm. 413(1-2), 10-18 (2011).