AMG-Tie2-1 是一种内皮细胞激酶 2 (Tie2) 的抑制剂，IC50 为 1 nM。 AMG-Tie2-1 是一种 VEGFR2 抑制剂，IC50 为 3 nM。
货号:ajcx20072
CAS:870223-96-4
分子式:C25H20F3N5O2
分子量：479.5
溶解度:DMF: 10mg/mL,DMSO: 10mg/mL,DMSO:PBS (pH 7.2) (1:2): 0.3mg/mL
纯度：98%
存储：Store at -20°C
库存：现货

Background:

AMG-Tie2-1 is an inhibitor of tunica interna endothelial cell kinase 2 (Tie2) and VEGF receptor 2 (VEGFR2) with IC50 values of 1 and 3 nM, respectively, in a homogenous time-resolved fluorescence (HTRF) assay.1 It inhibits angiopoietin 1-induced Tie2 autophosphorylation in EA.hy926 human endothelial cells (IC50 = 10 nM).

|1. Hodous, B.L., Geuns-Meyer, S.D., Hughes, P.E., et al. Evolution of a highly selective and potent 2-(pyridin-2-yl)-1,3,5-triazine Tie-2 kinase inhibitor. J. Med. Chem. 50(4), 611-626 (2007).