A neuropeptide with diverse biological activities
货号:ajcx21422
CAS:N/A
分子式:C19H30D3N3O8S.CF3COOH
分子量：580.6
溶解度:Water: 10 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

4-hydroxy Nonenal Glutathione-d₃(4-HNE-GSH-d₃(trifluoroacetate salt) contains three deuterium atoms at the terminal methyl position. It is intended for use as an internal standard for the quantification of 4-HNE-GSH (trifluoroacetate salt) by GC-or LC-mass spectrometry. 4-hydroxy-Nonenal (4-HNE) is a major aldehyde produced during the lipid peroxidation of ω-6 polyunsaturated fatty acids, such as arachidonic acid and linoleic acid.^1,24-HNE-GSH is a major adduct formed by the reaction of 4-HNE with GSH.^3,4,5,64-HNE-GSH levels in liver, plasma, or isolated cells can serve as biomarkers for oxidative stress.⁷The trapping of 4-HNE by glutathione to give HNE-GSH prevents the formation of DNA adducts with 4-HNE.^8,9In human polymorphonuclear leukocytes, HNE-GSH is metabolized to 1,4-dihydroxynonene glutathione (DHN-GSH), 4-hydroxynonenoic acid glutathione (HNA-GSH), and 4-hydroxy nonenal mercapturic acid (HNE-MA).³

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