A neuropeptide with diverse biological activities
货号:ajcx22498
CAS:N/A
分子式:C20H17D4F3N4O.HCl
分子量：430.9
溶解度:DMSO: slightly soluble,Methanol: slightly soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Flibanserin-d₄is intended for use as an internal standard for the quantification of flibanserin by GC- or LC-MS. Flibanserin is a full agonist of the serotonin 5-HT_1Areceptor and an antagonist of 5-HT_2A(K_is = 1 and 49 nM, respectively).¹It also binds to dopamine D₄receptors with K_ivalues ranging from 4-24 nM, but demonstrates no affinity for the other 5-HT subtypes or other neurotransmitter receptors.¹In vitro, flibanserin has been shown to reduce forskolin-stimulated cAMP formation in cells and rat tissues and to antagonize the accumulation of phosphatidyl inositol turnover induced by 5-HT in the mouse cortex.¹At 10 mg/kg, flibanserin can reduce serotonin in the prefrontal cortex and dorsal raphe of conscious rats while increasing extracellular noradrenaline and dopamine.¹

1.Invernizzi, R.W., Sacchetti, G., Parini, S., et al.Flibanserin, a potential antidepressant drug, lowers 5-HT and raises dopamine and noradrenaline in the rat prefrontal cortex dialysate: Role of 5-HT1A receptorsBr. J. Pharmacol.139(7)1281-1288(2003)