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Thioridazine-d3(hydrochloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Thioridazine-d3(hydrochloride)图片
包装:1mg
规格:98%
市场价:2769元
分子量:410.1

产品介绍
An internal standard for the quantification of thioridazine
货号:ajcx23604
CAS:1189928-36-6
分子式:C21H23D3N2S2.HCl
分子量:410.1
溶解度:Methanol: slightly soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Thioridazine-d3is intended for use as an internal standard for the quantification of thioridazine by GC- or LC-MS. Thioridazine is a typical antipsychotic.1It binds to dopamine D2, histamine H1, M3muscarinic, and α1- and α2-adrenergic receptors (Kis = 5-341.3 nM), as well as the serotonin (5-HT) receptor subtypes 5-HT1A, 5-HT2A, 5-HT2C, 5-HT6, and 5-HT7(Kis = 10-180.7 nM). Thioridazine (5 mg/kg) reduces amphetamine-induced repetitive head bobbing and oral behavior in rats.2It reduces conditioned fear stress-induced freezing behavior in rats when administered at doses ranging from 3 to 100 mg/kg.3Thioridazine is also active against multidrug-resistant tuberculosisin vitroandin vivo.4


1.Kroeze, W.K., Hufeisen, S.J., Popadak, B.A., et al.H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugsNeuropsychopharmacology28(3)519-526(2003) 2.Tschanz, J.T., and Rebec, G.V.Atypical antipsychotic drugs block selective components of amphetamine-induced stereotypyPharmacol. Biochem. Behav.31(3)519-522(1988) 3.Ishida-Tokuda, K., Ohno, Y., Sakamoto, H., et al.Evaluation of perospirone (SM-9018), a novel serotonin-2 and dopamine-2 receptor antagonist, and other antipsychotics in the conditioned fear stress-induced freezing behavior model in ratsJpn. J. Pharmacol.72(2)119-126(1996) 4.Amaral, L.Thioridazine: An old neuroleptic effective against totally drug resistant tuberculosisActa Med. Port.25(2)118-121(2012)