| 规格: | 98% |
| 分子量: | 168.6 |
| 包装 | 价格(元) |
| 500ug | 电议 |
| 1mg | 电议 |
Background:
Vigabatrin-13C-d2is intended for use as an internal standard for the quantification of vigabatrin by GC- or LC-MS. Vigabatrin is an irreversible GABA transaminase (GABA-T) inhibitor.1It inhibits rat brain GABA-T when used at a concentration of 0.1 mM. Vigabatrin is selective for rat brain GABA-T overP. fluorescensGABA-T at 10 mM and is 100-fold selective over glutamic acid decarboxylase (GAD). Vigabatrin (1,500 mg/kg) decreases brain GABA-T activity without affecting GAD activity in mice.2It reduces the incidence of myoclonus in a mouse model of audiogenic seizures.3Vigabatrin also increases the electroconvulsive threshold in mouse model of maximal electroshock-induced seizures and reduces the number of clonic convulsions induced by pentylenetetrazol in mice.4Formulations containing vigabatrin have been used in the treatment of seizures and infantile spasms.
1.Lippert, B., Metcalf, B.W., Jung, M.J., et al.4-Amino-hex-5-enoic acid, a selective catalytic inhibitor of 4-aminobutyric-acid aminotransferase in mammalian brainEur. J. Biochem.74(3)441-445(1977) 2.Jung, M.J., Lippert, B., Metcalf, B.W., et al.g-Vinyl GABA (4-amino-hex-5-enoic acid), A new selective irreversible inhibitor of GABA-T: Effects on brain GABA metabolism in miceJ. Neurochem.29(5)797-802(1977) 3.Meldrum, B.S., and Murugaiah, K.Anticonvulsant action in mice with sound-induced seizures of the optical isomers of g-vinyl GABAEur. J. Pharm.89(1-2)149-152(1983) 4.Luszczki, J.J., and Czuczwar, S.J.Isobolographic characterization of interactions between vigabatrin and tiagabine in two experimental models of epilepsyProg. Neuropsychopharmacol. Biol. Psychiatry31(2)529-538(2007)
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