Sitamaquine (WR 6026) tosylate 是一种具有口服活性的 8-氨基喹啉类似物，是一种抗寄生虫药。
货号:ajcx24078
CAS:1019640-33-5
分子式:C21H33N3O•C7H8O3S
分子量：515.7
溶解度:DMSO: 30 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Sitamaquine is an antileishmanial agent.¹It is active againstL. donovani,L. infantum,L. mexicana,L. braziliensis, andL. tropica(EC₅₀s = 9.5-19.8 µM). It inhibits mitochondrial complex II, also known as succinate dehydrogenase (SDH), in a cell-free assay when used at concentrations ranging from 10 to 200 µM.²Sitamaquine (100 µM) increases intracellular levels of reactive oxygen species (ROS) and decreases intracellular ATP levels, as well as induces phosphatidylserine externalization, chromatin fragmentation, and depolarization of the mitochondrial membrane potential, markers of apoptosis, inL. donovanipromastigotes.

1.LÓpez-MartÍn, C., PÉrez-Victoria, J.M., Carvalho, L., et al.Sitamaquine sensitivity in Leishmania species is not mediated by drug accumulation in acidocalcisomesAntimicrob. Agents Chemother.52(11)4030-4036(2008) 2.Carvalho, L.J.M., Luque-Ortega, J.R., LÓpez-MartÍn, C., et al.The 8-aminoquinoline analogue sitamaquine causes oxidative stress in Leishmania donovani promastigotes by targeting succinate dehydrogenaseAntimicrob. Agents Chemother.55(9)4204-4210(2011)