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Ticlopidine-d4(hydrochloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ticlopidine-d4(hydrochloride)图片
规格:98%
分子量:304.3
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
C14H10ClD4NS•HCl
货号:ajcx24616
CAS:N/A
分子式:C14H10ClD4NS•HCl
分子量:304.3
溶解度:DMSO: soluble,Methanol: soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Ticlopidine-d4is intended for use as an internal standard for the quantification of ticlopidine by GC- or LC-MS. Ticlopidine is a thienopyridine P2Y12receptor antagonist.1It inhibits aggregation of human platelets induced by collagen, arachidonic acid , and ADP .2It also inhibits ADP-induced aggregation of rat platelets and decreases thrombus weightin vivoin a rat model of arterio-venous shunt thrombosis when administered at a dose of 100 mg/kg.3Ticlopidine (300 mg/kg) inhibits healing of acetic acid-induced gastric ulcers in rats.4Formulations containing ticlopidine have been used in the prevention of thrombotic stroke.


1.Porto, I., Giubilato, S., De Maria, G.L., et al.Platelet P2Y12 receptor inhibition by thienopyridines: Status and futureExpert Opin. Investig. Drugs18(9)1317-1332(2009) 2.Bruno, J.J.The mechanisms of action of ticlopidineThromb. Res. Suppl.459-67(1983) 3.Sugidachi, A., Asai, F., Ogawa, T., et al.The in vivo pharmacological profile of CS-747, a novel antiplatelet agent with platelet ADP receptor antagonist propertiesBr. J. Pharmacol.129(7)1439-1446(2000) 4.Ma, L., Elliott, S.N., Cirino, G., et al.Platelets modulate gastric ulcer healing: Role of endostatin and vascular endothelial growth factor releaseProc. Nat. Acad. Sci. USA98(11)6470-6475(2001)