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Ginkgotoxin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ginkgotoxin图片
规格:98%
分子量:183.2
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
A neurotoxic pyridoxine antimetabolite
货号:ajcx24878
CAS:1464-33-1
分子式:C9H13NO3
分子量:183.2
溶解度:DMF: 1 mg/ml,DMSO: 5 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): 10 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Ginkgotoxin is a pyridoxine antimetabolite that has been found inG. biloba.1,2It inhibits pyridoxal kinase (Ki= 3 µM), the enzyme that converts pyridoxine into its active form, pyridoxal 5'-phosphate .3Ginkgotoxin (200-1,000 µM) induces seizure-like behavior in zebrafish larvae, an effect that can be reversed by PLP or GABA.4


1.Wada, K., Ishigaki, S., Ueda, K., et al.An antivitamin B6, 4'-methoxypyridoxine, from the seed of Ginkgo biloba L.Chem. Pharm. Bull.33(8)3555-3557(1985) 2.Arenz, A., Klein, M.K., Fiehe, K., et al.Occurrence of neurotoxic 4'-O-methylpyridoxine in Ginkgo biloba leaves, Ginkgo medications and Japanese Ginkgo foodPlanta Med.62(6)548-551(1996) 3.Gandhi, A.K., Desai, J.V., Ghatge, M.S., et al.Crystal structures of human pyridoxal kinase in complex with the neurotoxins, ginkgotoxin and theophylline: Insights into pyridoxal kinase inhibitionPLoS One7(7)e40954(2012) 4.Lee, G.-H., Sung, S.-Y., Chang, W.-N., et al.Zebrafish larvae exposed to ginkgotoxin exhibit seizure-like behavior that is relieved by pyridoxal-5'-phosphate, GABA and anti-epileptic drugsDis. Model. Mech.5(6)785-795(2012)