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Dolasetron-d4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Dolasetron-d4图片
规格:98%
分子量:328.4
包装与价格:
包装价格(元)
500ug电议
1mg电议

产品介绍
An internal standard for the quantification of dolasetron
货号:ajcx25090
CAS:N/A
分子式:C19H16D4N2O3
分子量:328.4
溶解度:Acetone: soluble,Acetonitrile: soluble,DMSO: soluble,Methanol: soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Dolasetron-d4is intended for use as an internal standard for the quantification of dolasetron by GC- or LC-MS. Dolasetron is an antagonist of the serotonin (5-HT) receptor subtype 5-HT3(Ki= 20 nM).1It is selective for 5-HT3receptors over 5-HT1A, 5-HT1B, 5-HT2, dopamine D2, α1-, α2-, and β-adrenergic, M1-5muscarinic acetylcholine, and neurokinin-1 (NK1) receptors (IC50s = >10 µM for all).2Dolasetron inhibits 5-HT-induced membrane currents in NG 108-15 cells (IC50= 3.8 nM).1It increases the latency to emesis and reduces the number of vomiting and retching episodes induced by cisplatin in ferrets when administered at doses of 0.5 or 2 mg/kg.2Formulations containing dolasetron have been used in the prevention of postoperative or chemotherapy-induced nausea.


1.Beoijinga, P.H., Galvan, M., Baron, B.M., et al.Characterization of the novel 5-HT3 antagonists MDL 73147EF (dolasetron mesilate) and MDL 74156 in NG108-15 neuroblastoma x glioma cellsEur. J. Pharmacol.219(1)9-13(1992) 2.Miller, R.C., Galvan, M., Gittos, M.W., et al.Pharmacological properties of dolasetron, a potent and selective antagonist at 5-HT3 receptorsDrug Develop. Res.28(1)87-93(1993)