A derivative of acetaminophen
货号:ajcx25108
CAS:621-42-1
分子式:C8H9NO2
分子量：151.2
溶解度:DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:4): 0.20 mg/ml,Ethanol: 5 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Metacetamol is a derivative of acetaminophen .^1,2,3Unlike acetaminophen, metacetamol is not cytotoxic to isolated mouse hepatocytes (LC₅₀= >10 mM).¹However, it does induce necrosis and depletion of glutathione (GSH) in isolated human hepatocytes when used at a concentration of 10 mM.²Metacetamol (900 mg/kg) does not induce hepatic necrosis in mice.³

1.Holme, J.A., Hongslo, J.K., BjØrge, C., et al.Comparative cytotoxic effects of acetaminophen (N-acetyl-p-aminophenol), a non-hepatotoxic regioisomer acetyl-m-aminophenol and their postulated reactive hydroquinone and quinone metabolites in monolayer cultures of mouse hepatocytesBiochem. Pharmacol.42(5)1137-1142(1991) 2.Xie, Y., McGill, M.R., Du, K., et al.Mitochondrial protein adducts formation and mitochondrial dysfunction during N-acetyl-m-aminophenol (AMAP)-induced hepatotoxicity in primary human hepatocytesToxicol. Appl. Pharmacol.289(2)213-222(2015) 3.Nelson, E.B.The pharmacology and toxicology of meta-substituted acetanilide I: Acute toxicity of 3-hydroxyacetanilide in miceRes. Commun. Chem. Pathol. Pharmacol.28(3)447-456(1980)