A phagocytosis-stimulating peptide
货号:ajcx25176
CAS:N/A
分子式:C21H40N8O6·XCF3COOH
分子量：500.6
溶解度:DMF: 25 mg/ml,DMSO: 20 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 10 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Tuftsin is an endogenous peptide generated by proteolysis of leukokinin that stimulates phagocytosis.¹It binds human polymorphonuclear leukocytes (PMN), human monocytes, and mouse macrophages with K_dvalues of 130, 125, and 53 nM, respectively.²Tuftsin (200 nM) increases phagocytosis of IgG-coated ovine red blood cells by 61% in isolated mouse peritoneal macrophages. It increases phagocytosis of the bacteriaS. aureusandL. monocytogenes, as well as the fungusS. oviformis, by isolated human, mouse, rabbit, dog, or guinea pig phagocytes when used at concentrations ranging from 0.01 to 0.15 µg/ml.³Tuftsin (0.1, 0.5, and 25 mg/kg) increases survival in a syngeneic mouse model of 2-methylcholanthrene-induced fibrosarcoma.⁴

1.Najjar, V.A., and Nishioka, K."Tuftsin": A natural phagocytosis stimulating peptideNature228(5272)672-673(1970) 2.Gottlieb, P., Stabinsky, Y., Hiller, T., et al.Tuftsin receptorsAnn. N. Y. Acad. Sci.41993-106(1983) 3.Martinez, J., and Winternitz, F.Bactericidal activity of tuftsinMol. Cell Biochem.41123-136(1981) 4.Catane, R., Schlanger, S., Weiss, L., et al.Toxicology and antitumor activity of tuftsinAnn. N. Y. Acad. Sci.419251-260(1983)