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LAMP1 Monoclonal Antibody(Clone Ly1C6)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
规格:98%
分子量:120
包装与价格:
包装价格(元)
25ug电议
100ug电议

产品介绍
For immunochemical analysis of LAMP1
货号:ajcx25892
CAS:N/A
分子式:N/A
分子量:120
溶解度:N/A
纯度:98%
存储:Store at -20°C
库存:现货

Background:


Lysosome associated membrane protein 1 (LAMP1) and LAMP2 are major constituents of the lysosomal membrane. The two have closely related structures, with 37% sequence homology.1They are both transmembrane glycoproteins that are localized primarily in lysosomes and late endosomes. Newly synthesized molecules are mostly transported from the trans-Golgi network directly to endosomes and then to lysosomes. A second pathway involves the LAMPs being delivered from the Golgi to the cell surface, and then along the endocytic pathway to the lysosomes. A minor pathway involves transportviathe plasma membrane.2Upon stimulation, a rapid translocation of intracellular LAMPs to the cell membrane is dependent on a carboxyl-terminal tyrosine based motif (YXXI).3If there is a disturbance in this spacing, lysosome localization of LAMP1 is abolished and the mutant protein then cycles between the membrane and the endosome.2This stimulation has also been shown to have an associated release of histamine, leukotriene C4and prostaglandin D2, which shows that LAMP1 and LAMP2 are activation markers for normal mast cells.3They have also been linked to the inflammatory response in that they promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium and therefore possibly adhesion of PBMC to the site of inflammation.4


1.HÖning, S., Sandoval, I.V., and von Figura, K.A di-leucine-based motif in the cytoplasmic tail of LIMP-II and tyrosinase mediates selective binding of AP-3EMBO Journal17(5)1304-1314(1998) 2.Rohrer, J., Schweizer, A., Russel, D., et al.The targeting of lamp1 to lysosomes is dependent on the spacing of its cytoplasmic tail tyrosine sorting motif relative to the membraneJournal of Cell Biology132(4)565-576(1996) 3.GrÜtzkau, A., Smorodchenko, A., Lippert, U., et al.LAMP-1 and LAMP-2, but not LAMP-3, are reliable markers for activation-induced secretion of human mast cellsCytometry Part A61(1)62-68(2004) 4.Kannan, K., Stewart, R.M., Bounds, W., et al.Lysosome-associated membrane proteins h-LAMP1 (CD107a) and h-LAMP2 (CD107b) are activation-dependent cell surface glycoproteins in human peripheral blood mononuclear cells which mediate cell adhesion to vascular endotheliumCellular Immunology171(1)10-19(1996)