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Orexin B amide(mouse,rat)(trifluoroacetate salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Orexin B amide(mouse,rat)(trifluoroacetate salt)图片
包装:1mg
规格:98%
市场价:4513元
分子量:2936.4

产品介绍
A hypothalamic neuropeptide
货号:ajcx26060
CAS:N/A
分子式:C126H215N45O34S • XCF3COOH
分子量:2936.4
溶解度:Water: soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:


Orexin B is a hypothalamic neuropeptide that regulates feeding behavior, wakefulness, and behavior under situations of high motivational relevance.1The sequence of mouse orexin B is identical to the rat sequence and differs from the human sequence at only two residues.2Orexin B is an agonist of orexin receptors (OXRs) that increases intracellular calcium mobilization in HEK293 cells expressing OX1R or OX2R (EC50s = 0.93 and 0.13 µM, respectively).3


1.Mahler, S.V., Moorman, D.E., Smith, R.J., et al.Motivational activation: A unifying hypothesis of orexin/hypocretin functionNat. Neurosci.17(10)1298-1303(2014) 2.Sakurai, T., Amemiya, A., Ishii, M., et al.Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviorCell92(4)573-585(1998) 3.Lang, M., SÖll, R.M., DÜrrenberger, F., et al.Structure-activity studies of orexin A and orexin B at the human orexin 1 and orexin 2 receptors led to orexin 2 receptor selective and orexin 1 receptor preferring ligandsJ. Med. Chem.47(5)1153-1160(2004)